منابع مشابه
Gat1 (Gaba:Na+:Cl−) Cotransport Function
Neurotransmitter transporters are reported to mediate transmembrane ion movements that are poorly coupled to neurotransmitter transport and to exhibit complex "channel-like" behaviors that challenge the classical "alternating access" transport model. To test alternative models, and to develop an improved model for the Na+- and Cl--dependent gamma-aminobutyric acid (GABA) transporter, GAT1, we e...
متن کاملCotransport Function Database Reconstruction with an Alternating Access Model
We have developed an alternating access transport model that accounts well for GAT1 (GABA:Na 1 : Cl 2 ) cotransport function in Xenopus oocyte membranes. To do so, many alternative models were fitted to a database on GAT1 function, and discrepancies were analyzed. The model assumes that GAT1 exists predominantly in two states, E in and E out . In the E in state, one chloride and two sodium ions...
متن کاملEnhanced learning and memory in GAT1 heterozygous mice.
γ-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the central nervous system. The termination of GABA transmission is through the action of a family of membrane proteins, called GABA transporters (GAT1-4). It is well established that GABA system is involved in the modulation of memory. Our previous study showed that homozygous GAT1(-/-) mice exhibited impaired hippocampus-d...
متن کاملSodium-potassium-chloride cotransport.
Obligatory, coupled cotransport of Na(+), K(+), and Cl(-) by cell membranes has been reported in nearly every animal cell type. This review examines the current status of our knowledge about this ion transport mechanism. Two isoforms of the Na(+)-K(+)-Cl(-) cotransporter (NKCC) protein (approximately 120-130 kDa, unglycosylated) are currently known. One isoform (NKCC2) has at least three altern...
متن کاملCoordinate modulation of Na-K-2Cl cotransport and K-Cl cotransport by cell volume and chloride.
Na-K-2Cl cotransporter (NKCC) and K-Cl cotransporter (KCC) play key roles in cell volume regulation and epithelial Cl(-) transport. Reductions in either cell volume or cytosolic Cl(-) concentration ([Cl(-)](i)) stimulate a corrective uptake of KCl and water via NKCC, whereas cell swelling triggers KCl loss via KCC. The dependence of these transporters on volume and [Cl(-)](i) was evaluated in m...
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ژورنال
عنوان ژورنال: Journal of General Physiology
سال: 1999
ISSN: 0022-1295,1540-7748
DOI: 10.1085/jgp.114.3.459