Gastric Syphilis and Membranous Glomerulonephritis

Gastric Syphilis and Membranous Glomerulonephritis

Syphilis is a chronic systemic infectious disease caused by the bacterium Treponema pallidum. Gastric involvement and nephrotic syndrome are uncommon but well documented complications of syphilis, but the co-occurrence of these two complications in the same patient is extremely rare. Thus, because of their nonspecific presentation, suspicion of gastric syphilis (GS) and nephrotic syndrome is es...

Membranous glomerulonephritis secondary to syphilis.

Stanley de Almeida Araújo, Luiz Flávio Giordano , Ariel Augusto de Britto Rosa , Paula Alves Santos do Carmo, Kinulpe Honorato-Sampaio a Escola de Medicina da Universidade Federal de Ouro Preto, Ouro Preto, MG, Brazil b Centro Especializado em Anatomia Patológica, Belo Horizonte, MG, Brazil c Hospital Universitário São José, Belo Horizonte, MG, Brazil d Centro de Microscopia da Universidade Fed...

Membranous glomerulonephritis in a patient with syphilis.

Mesangial cells in membranous glomerulonephritis.

Renal biopsies of seven patients with membranous glomerulonephritis were examined by light, electron, and immunofluorescence microscopy. All had characteristic changes of glomerular basement membranes, typically with bright granular membranous fluorescence of IgG and variable deposits of complement. Cellularity was normal or slightly increased due largely to mesangial cell proliferation. These ...

Immunological Basis of Membranous Glomerulonephritis

Primary membranous glomerulonephritis (MGN) is a major glomerular disease causing proteinuria in humans (Jones, 1957). It is the prototype of an autoimmune disease (Couser, et al., 1978) characterized by sub-epithelial immune deposits within glomeruli. Its pathogenesis remains still unknown. Immune deposits are formed by IgG4, their respective antigen and complement. The definition of the immun...