Gastric amphicrine carcinoma: A histopathological diagnostic conundrum

Amphicrine carcinoma is rarely reported in literature. It characterised by dual positivity of neuroendocrine markers and mucin stain the same cells depicting divergent differentiation. Recently published WorldHealth Organisation (WHO) classification neoplasm 2022 differentiates it from adenocarcinoma mixed neuroendocrine-nonneuroendocrine neoplasms (MiNEN) shows varied histomorphology on rare occasions features may not be evident poorly differentiated carcinoma. Hence, diagnosis based solely can misleading. This a case amphicrine an elderly female which showed morphology along with signet ring cells. Same demonstrated immunopositivity for synaptophysin, chromogranin A were also positive stains (PAS, PAS-D Alcian blue). report, thus, emphasises importance as part routine immunohistochemistry gastric carcinomas to aid