Garlic inhibitory effect on platelet activity induced by different agonists


 Platelets are essential elements of human blood. In addition to their normal role, platelets involved in causing myocardial infarction, stroke and other thrombotic disorders. Platelet activation vivo, probably involves a combination agonists. Garlic has beneficial effects due its ability inhibit platelet aggregation thromboxane formation. The aim this work was evaluate the garlic extracts induced by different agonists mixtures donors. Significant differences were found response each agonist (P ≤ 0.05). highest antiaggregatory effect observed with arachidonic acid lowest collagen-arachidonic mixture. Interaction between donor (or mixtures) detected. study showed potential aqueous prevent agonist.
 Highlights
 play central role progression atherosclerotic lesions.
 Blood from nine non-smoker healthy donors used for vitro study.
 Aqueous could