gamma-Glutamyl amino acids. Transport and conversion to 5-oxoproline in the kidney.
نویسندگان
چکیده
منابع مشابه
A gamma-glutamyl transpeptidase-independent pathway of glutathione catabolism to glutamate via 5-oxoproline in Arabidopsis.
The degradation pathway of glutathione (GSH) in plants is not well understood. In mammals, GSH is predominantly metabolized through the gamma-glutamyl cycle, where GSH is degraded by the sequential reaction of gamma-glutamyl transpeptidase (GGT), gamma-glutamyl cyclotransferase, and 5-oxoprolinase to yield glutamate (Glu) and dipeptides that are subject to peptidase action. In this study, we ex...
متن کاملThe reaction of glutathione with amino acids and related compounds as catalyzed by gamma-glutamyl transpeptidase.
In a previous publication (1) methods were described which permit the quantitative estimation of the action of y-glutamyl transpeptidase upon glutathione. In the present report these methods are employed to study the influence of amino acids. pcptides, and other compounds upon the reaction. In addition, we present the results of attempts to account for all the main products formed in the reacti...
متن کاملPeptide transport in bacteria: methods, mutants and energy coupling.
yglutamyl amino acids and for glutathione. Transport of y-glutamylmethionine is associated with markedly increased renal 5-oxoproline formation, indicating that transported dipeptide serves as a substrate of intracellular yglutamylcyclotransferase (R. J. Bridges & A. Meister, unpublished work). Previous investigations showed that renal 5-oxoproline levels are significantly elevated after admini...
متن کاملIn vivo conversion of 5-oxoproline to glutamate by higher plants.
l-(U-(14)C)-5-oxoproline (pyrollidone carboxylic acid or pyroglutamic acid) was infiltrated into detached leaves of a number of species and incubated for 1 to 6 hours. In every case, conversion to labeled glutamate and glutamine was observed. The amount converted varied from 1 to 64% of the total label fed depending on the species. The ratio of glutamate-(14)C to glutamine-(14)C ranged from 5 i...
متن کاملTransport of amino acids.
Before amino acids nourish the cell they must be transported a) across the intestinal mucosa and b) across the plasma membrane of the cell where they are to be used. In addition, full consideration of their economy in the animal organism must include also their entry into the liver and their resorption from the renal tubule. All of these events appear to have much in common and probably to repr...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1985
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(17)39607-2