Gamma camera characterization at high holmium-166 activity in liver radioembolization
نویسندگان
چکیده
منابع مشابه
Holmium-166 radioembolization for the treatment of patients with liver metastases: design of the phase I HEPAR trial
BACKGROUND Intra-arterial radioembolization with yttrium-90 microspheres ( 90Y-RE) is an increasingly used therapy for patients with unresectable liver malignancies. Over the last decade, radioactive holmium-166 poly(L-lactic acid) microspheres ( 166Ho-PLLA-MS) have been developed as a possible alternative to 90Y-RE. Next to high-energy beta-radiation, 166Ho also emits gamma-radiation, which al...
متن کاملSurefire infusion system versus standard microcatheter use during holmium-166 radioembolization: study protocol for a randomized controlled trial
BACKGROUND An anti-reflux catheter (ARC) may increase the tumor absorbed dose during radioembolization (RE) by elimination of particle reflux and its effects on hemodynamics. Since the catheter is fixed in a centro-luminal position, it may also increase the predictive accuracy of a scout dose administration before treatment. The purpose of the SIM trial is to compare the effects of ARC use duri...
متن کاملProduction of Holmium-166 DOTMP: A promising agent for bone marrow ablation in hematologic malignancies
Intoduction: Therapeutic radiopharmaceuticals are radiolabeled molecules to deliver sufficient doses of ionizing radiation to specific disease sites such as bone metastases, brain and liver tumors and bone marrows malignancies including multiple myeloma. Among some therapeutic radiopharmaceuticals, 166Ho-1,4,7,10 -tetraazacyclo dodecane-1,4,7,10 tetraethy...
متن کاملQuantitative Evaluation of Scintillation Camera Imaging Characteristics of Isotopes Used in Liver Radioembolization
BACKGROUND Scintillation camera imaging is used for treatment planning and post-treatment dosimetry in liver radioembolization (RE). In yttrium-90 (90Y) RE, scintigraphic images of technetium-99m (99mTc) are used for treatment planning, while 90Y Bremsstrahlung images are used for post-treatment dosimetry. In holmium-166 (166Ho) RE, scintigraphic images of 166Ho can be used for both treatment p...
متن کاملFeasibility of high activity rhenium-188-microsphere in hepatic radioembolization.
BACKGROUND This paper describes the feasibility of intra-arterial high-activity administration of (188)Re-microspheres. METHODS Patients with unresectable colorectal liver metastases or hepatocellular cancer (HCC) received single treatments with (188)Re-microspheres. The administered activity was calculated to give a liver dose of 100 Gy. From post-therapeutic scans and urine sampling, the do...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: EJNMMI Physics
سال: 2021
ISSN: 2197-7364
DOI: 10.1186/s40658-021-00372-9