Gallic acid analogues with antibreast cancer and antioxidant action: synthesis and pharmacological assessment

Breast cancer is one of the important public health problems today and recent treatments have not been found to be very effective for advanced-stage metastatic disease breast. In present study ten 3,4,5- trihydroxybenzohy- drazone derivatives (AR 01- AR 10) were synthesized by two different methods viz. reflux stirring. It was observed that compounds stirring method acquire good yield require less time in comparison method. Further cytotoxicity activity performed on breast cell lines MDA-MB-468 MCF-7 revealed moderate all at 40 μg/mL 80 which has highest samples 01 10 both lines. Considerably shown potent antioxidant 50 above concentrations. Tumor mice treated with compound smaller control 10. Findings having electron donating group showed more against vitro vivo. Cytotoxicity also corelates QSAR positive contribution towards toxicity. These findings suggest gallic acid cytotoxic may provide therapeutic effects cancer.