Galactose-α-1,3-Galactose: Atypical Food Allergen or Model IgE Hypersensitivity?
نویسندگان
چکیده
منابع مشابه
Galactose-α-1,3-galactose-specific IgE is associated with anaphylaxis but not asthma.
RATIONALE IgE antibodies to the mammalian oligosaccharide galactose-α-1,3-galactose (α-gal) are common in the southeastern United States. These antibodies, which are induced by ectoparasitic ticks, can give rise to positive skin tests or serum assays with cat extract. OBJECTIVES To evaluate the relationship between IgE antibodies to α-gal and asthma, and compare this with the relationship bet...
متن کاملDrug allergens and food--the cetuximab and galactose-α-1,3-galactose story.
OBJECTIVE A novel form of food allergy has been described that initially became apparent from IgE reactivity with the drug cetuximab. Ongoing work regarding the etiology, distribution, clinical management, and cellular mechanisms of the IgE response to the oligosaccharide galactose-α-1,3-galactose (α-gal) is reviewed. DATA SOURCES Brief review of the relevant literature in peer-reviewed journ...
متن کاملThe relevance of tick bites to the production of IgE antibodies to the mammalian oligosaccharide galactose-α-1,3-galactose.
BACKGROUND In 2009, we reported a novel form of delayed anaphylaxis to red meat that is related to serum IgE antibodies to the oligosaccharide galactose-α-1,3-galactose (alpha-gal). Most of these patients had tolerated meat for many years previously. The implication is that some exposure in adult life had stimulated the production of these IgE antibodies. OBJECTIVES We sought to investigate p...
متن کاملImmunoproteomics of processed beef proteins reveal novel galactose-α-1,3-galactose-containing allergens.
BACKGROUND Red meat allergy presents a novel form of food allergy with severe delayed allergic reactions where IgE antibodies are directed against the carbohydrate α-Gal epitope. Food preparation and processing can influence the allergenicity of proteins. The aim of this study was to characterize the proteomic profile of different beef preparations and to investigate their α-Gal reactivity and ...
متن کاملGalactose-α-1,3-galactose and delayed anaphylaxis, angioedema, and urticaria in children.
BACKGROUND AND OBJECTIVE Despite a thorough history and comprehensive testing, many children who present with recurrent symptoms consistent with allergic reactions elude diagnosis. Recent research has identified a novel cause for "idiopathic" allergic reactions; immunoglobulin E (IgE) antibody specific for the carbohydrate galactose-α-1,3-galactose (α-Gal) has been associated with delayed urtic...
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ژورنال
عنوان ژورنال: Current Allergy and Asthma Reports
سال: 2017
ISSN: 1529-7322,1534-6315
DOI: 10.1007/s11882-017-0672-7