GAF domain-induced activation of phosphodiesterases 2 and 5
نویسندگان
چکیده
منابع مشابه
GAF domain-induced activation of phosphodiesterases 2 and 5
The second messenger cGMP is involved in several physiological functions such as smooth muscle relaxation and inhibition of platelet aggregation. Besides cGMP synthesis, hydrolysis of cGMP by cyclic nucleotide phosphodiesterases (PDEs) determines the shape of cGMP signals. Eleven PDE families are known differing in regulation and cAMP/cGMP specificity. PDEs are homodimers; each monomer being co...
متن کاملMINIREVIEW Properties and Functions of GAF Domains in Cyclic Nucleotide Phosphodiesterases and Other Proteins
This review focuses primarily on our current understanding of the structure and function of GAF domains in cyclic nucleotide phosphodiesterases (PDEs). The GAF domain was originally identified by Aravind and Ponting (1997) using the position-specific iterative BLAST method (Altschul et al., 1997). The consensus sequence defining GAF domains is taken from a characteristic primary sequence of che...
متن کاملProperties and functions of GAF domains in cyclic nucleotide phosphodiesterases and other proteins.
This review focuses primarily on our current understanding of the structure and function of GAF domains in cyclic nucleotide phosphodiesterases (PDEs). The GAF domain was originally identified by Aravind and Ponting (1997) using the position-specific iterative BLAST method (Altschul et al., 1997). The consensus sequence defining GAF domains is taken from a characteristic primary sequence of che...
متن کاملSodium regulation of GAF domain function.
Cyclic nucleotide PDEs (phosphodiesterases) regulate cellular levels of cAMP and cGMP by controlling the rate of degradation. Several mammalian PDE isoforms possess N-terminal GAF (found in cGMP PDEs, Anabaena adenylate cyclases and Escherichia coli FhlA; where FhlA is formate hydrogen lyase transcriptional activator) domains that bind cyclic nucleotides. Similarly, the CyaB1 and CyaB2 ACs (ade...
متن کاملTranscription factors GAF and HSF act at distinct regulatory steps to modulate stress-induced gene activation.
The coordinated regulation of gene expression at the transcriptional level is fundamental to development and homeostasis. Inducible systems are invaluable when studying transcription because the regulatory process can be triggered instantaneously, allowing the tracking of ordered mechanistic events. Here, we use precision run-on sequencing (PRO-seq) to examine the genome-wide heat shock (HS) re...
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ژورنال
عنوان ژورنال: BMC Pharmacology
سال: 2009
ISSN: 1471-2210
DOI: 10.1186/1471-2210-9-s1-p28