Gadolinium-based compounds induce NLRP3-dependent IL-1β production and peritoneal inflammation
نویسندگان
چکیده
منابع مشابه
Calcium oxalate crystals induce renal inflammation by NLRP3-mediated IL-1β secretion.
Nephrocalcinosis, acute calcium oxalate (CaOx) nephropathy, and renal stone disease can lead to inflammation and subsequent renal failure, but the underlying pathological mechanisms remain elusive. Other crystallopathies, such as gout, atherosclerosis, and asbestosis, trigger inflammation and tissue remodeling by inducing IL-1β secretion, leading us to hypothesize that CaOx crystals may induce ...
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Sterile particles induce robust inflammatory responses that underlie the pathogenesis of diseases like silicosis, gout, and atherosclerosis. A key cytokine mediating this response is IL-1β. The generation of bioactive IL-1β by sterile particles is mediated by the NOD-like receptor containing a pyrin domain 3 (NLRP3) inflammasome, although exactly how this occurs is incompletely resolved. Prior ...
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Basic calcium phosphate (BCP) crystals are associated with severe osteoarthritis and acute periarticular inflammation. Three main forms of BCP crystals have been identified from pathological tissues: octacalcium phosphate, carbonate-substituted apatite, and hydroxyapatite. We investigated the proinflammatory effects of these BCP crystals in vitro with special regard to the involvement of the NL...
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ژورنال
عنوان ژورنال: Annals of the Rheumatic Diseases
سال: 2014
ISSN: 0003-4967,1468-2060
DOI: 10.1136/annrheumdis-2013-204900