منابع مشابه
GABA and benzodiazepine receptors in basal ganglia function.
GABA and its associated benzodiazepine interactions play an important role in basal ganglia function. Distinctive GABA, benzodiazepine and opiate receptor changes occur in response to striatal lesions and in the human neurodegenerative disorder, Huntington's disease (HD). In animal experiments, the in vivo administration of [3H]flunitrazepam labels benzodiazepine receptors and can demonstrate t...
متن کاملNervous System Membrane Proteins Heterogeneity of GABA,-benzodiazepine receptors
Introduction The GABAA receptor of mammalian brain is a ligand-gated chloride ion channel and the site of action of a variety of pharmacologically and clinically important drugs. Thus, electrophysiological experiments in many different systems have indicated that the anxiolytic, anticonvulsant, muscle relaxant and sedative hypnotic benzodiazepines like diazepam or flunitrazepam enhance and some...
متن کاملGABA and benzodiazepine receptors in the gerbil brain after transient ischemia: demonstration by quantitative receptor autoradiography.
Quantitative receptor autoradiography was used to measure the binding of gamma-aminobutyric acid (GABA) and benzodiazepine receptors after ischemia by means of transient occlusion of bilateral common carotid arteries in the gerbil. [3H]Muscimol was used to label the GABAA receptors and [3H]flunitrazepam to label central type benzodiazepine receptors. In the superolateral convexities of the fron...
متن کاملGABA regulation of circadian responses to light. I. Involvement of GABAA-benzodiazepine and GABAB receptors.
Light-induced phase shifts of the circadian locomotor rhythm of hamsters can be blocked by agents that alter GABA neurotransmission. The GABA antagonist bicuculline blocks phase delays induced by light and the benzodiazepine diazepam, which can potentiate GABA activity, blocks light-induced phase advances. In the experiments reported here, we found that the bicuculline blockade of phase delays ...
متن کاملDistribution and lateral mobility of GABA/benzodiazepine receptors on nerve cells.
The distribution and mobility of GABA/benzodiazepine receptors has been examined on living nerve cells by fluorescence digital imaging and fluorescence photobleach recovery with 2 novel fluorescent derivatives of the benzodiazepines Ro7-1986 and 1012S. These fluorescent derivatives retain their high affinity for the GABA/benzodiazepine receptor complex with Ks of 79 and 85 nM, respectively. Dig...
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ژورنال
عنوان ژورنال: Nature
سال: 1978
ISSN: 0028-0836,1476-4687
DOI: 10.1038/275477a0