G-quadruplexes mediate local translation in neurons
نویسندگان
چکیده
منابع مشابه
RNA G-quadruplexes and their potential regulatory roles in translation
DNA guanine (G)-rich 4-stranded helical nucleic acid structures called G-quadruplexes (G4), have been extensively studied during the last decades. However, emerging evidence reveals that 5'- and 3'-untranslated regions (5'- and 3'-UTRs) as well as open reading frames (ORFs) contain putative RNA G-quadruplexes. These stable secondary structures play key roles in telomere homeostasis and RNA meta...
متن کامل5′-UTR RNA G-quadruplexes: translation regulation and targeting
RNA structures in the untranslated regions (UTRs) of mRNAs influence post-transcriptional regulation of gene expression. Much of the knowledge in this area depends on canonical double-stranded RNA elements. There has been considerable recent advancement of our understanding of guanine(G)-rich nucleic acids sequences that form four-stranded structures, called G-quadruplexes. While much of the re...
متن کاملAnchoring Local Translation in Neurons
In probing how protein synthesis in neurons is coupled to extracellular stimuli, Tcherkezian et al. (2010) discover that the receptor protein DCC anchors components of the translation machinery at the plasma membrane. Binding of DCC to its ligand, netrin, triggers the release of these components to initiate spatially restricted protein synthesis.
متن کاملmRNA transport & local translation in neurons.
Neurons are amongst the most structurally complex cells and exhibit a high degree of spatial compartmentalization. Also, neurons exhibit rapid and dynamic signaling by processing information in a precise and, sometimes, spatially-restricted manner. The signaling that occurs in axons and dendrites necessitates the maintenance and modification of their local proteomes. Local translation of mRNAs ...
متن کاملComplicated behavior of G-quadruplexes and evaluating G-quadruplexes' ligands in various systems mimicking cellular circumstance
Environments surrounding G-rich sequences remarkably affect the conformations of these structures. A proper evaluation system mimicking the crowded environment in a cell with macromolecules should be developed to perform structural and functional studies on G-quadruplexes. In this study, the topology and stability of a G-quadruplex formed by human telomeric repeat sequences were investigated in...
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ژورنال
عنوان ژورنال: Biochemical Society Transactions
سال: 2015
ISSN: 0300-5127,1470-8752
DOI: 10.1042/bst20150053