G-quadruplex virtual drug screening: A review
نویسندگان
چکیده
منابع مشابه
Identification of new natural DNA G-quadruplex binders selected by a structure-based virtual screening approach.
The G-quadruplex DNA structures are mainly present at the terminal portion of telomeres and can be stabilized by ligands able to recognize them in a specific manner. The recognition process is usually related to the inhibition of the enzyme telomerase indirectly involved and over-expressed in a high percentage of human tumors. There are several ligands, characterized by different chemical struc...
متن کاملIn silico screening of G-Quadruplex Structures in Wilms tumor 1 Gene Promoter
Introduction: X-ray diffraction studies have revealed that guanines in a DNA stands may be arranged in quartet and form a structure called G-quadruplexs. Bioinformatics studies suggested the formation of G-quadruplex structure in human crucial genes, including Wilms tumor 1 (WT1). The aim of this study was to in silico analysis of the guanine-rich sequence in the promoter region of the WT1 gene...
متن کاملA mRNA-Responsive G-Quadruplex-Based Drug Release System
G-quadruplex-based drug delivery carriers (GDDCs) were designed to capture and release a telomerase inhibitor in response to a target mRNA. Hybridization between a loop on the GDDC structure and the mRNA should cause the G-quadruplex structure of the GDDC to unfold and release the bound inhibitor, anionic copper(II) phthalocyanine (CuAPC). As a proof of concept, GDDCs were designed with a 10-30...
متن کاملLabel-free fluorescence method for screening G-quadruplex ligands.
G-quadruplex ligands can interfere with the telomere structure, telomere elongation/replication, and proliferation of cancer cells. A key element in the development of potent G-quadruplex ligands is the screening of large chemical libraries of potential candidates. Here, we describe a simple fluorescence method for screening of G-quadruplex ligands. The method is based on the ability of G-quadr...
متن کاملTri-G-quadruplex: controlled assembly of a G-quadruplex structure from three G-rich strands.
In my (DNA) dreams: A tri-G-quadruplex was constructed from three strands (T1-T3) of DNA using duplex formation to guide the G-rich tracts into close proximity with the addition of Li(+) ions (see scheme). The defined G-quadruplex structure was formed upon addition of Na(+) ions and characterized by gel electrophoresis and spectroscopy.
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ژورنال
عنوان ژورنال: Biochimie
سال: 2018
ISSN: 0300-9084
DOI: 10.1016/j.biochi.2018.06.024