G protein‐coupled receptors: walking hand‐in‐hand, talking hand‐in‐hand?

G protein-coupled receptors: walking hand-in-hand, talking hand-in-hand?

Most cells express a panel of different G protein-coupled receptors (GPCRs) allowing them to respond to at least a corresponding variety of extracellular ligands. In order to come to an integrative well-balanced functional response these ligand-receptor pairs can often cross-regulate each other. Although most GPCRs are fully capable to induce intracellular signalling upon agonist binding on the...

Walking & Talking - Sharing best practice

Moving towards more communication intensive organizations where work tends to become more mobile there is a growing need to support learning among knowledge workers. This paper reports on a study of a group of knowledge workers, working both closely together and sometimes geographically separated was carried out in order to find out how and when learning took place and when the need for learnin...

Molecular motors: Walking talking heads

Small tension signals that pass between the two linked heads of kinesin allow the motor protein to coordinate its walking action. Two new studies suggest that certain members of the two other major families of motor proteins, the myosins and dyneins, can do the same thing.

Commentary: on walking and talking.

I welcome Dr. Kapoor's reflections on psychotherapy with offender patients. In this commentary, I will discuss the value of psychodynamic psychotherapy in the treatment of forensic patients and some of the technical competencies required. I hope that these thoughts, and Dr. Kapoor's fine writing, will inspire other forensic practitioners to practice psychodynamic forensic psychiatry and to util...

Talking without Walking: Canada’s Ineffective Climate Effort