Future of Cholesteryl Ester Transfer Protein (CETP) Inhibitors: A Pharmacological Perspective
نویسندگان
چکیده
منابع مشابه
Cholesteryl Ester Transfer Protein (CETP) Deficiency and CETP Inhibitors
Epidemiologic studies have shown that low-density lipoprotein cholesterol (LDL-C) is a strong risk factor, whilst high-density lipoprotein cholesterol (HDL-C) reduces the risk of coronary heart disease (CHD). Therefore, strategies to manage dyslipidemia in an effort to prevent or treat CHD have primarily attempted at decreasing LDL-C and raising HDL-C levels. Cholesteryl ester transfer protein ...
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Cholesteryl ester transfer protein (CETP), a plasma glycoprotein, mediates the transfer of neutral lipids in the blood among various lipoproteins.1,2 Because of their poor water solubility, neutral lipids such as triglycerides (TG), free cholesterol (FC), and cholesteryl esters (CE) generally are not freely circulating in plasma but instead are packaged together and transported through the body...
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Despite tremendous progress made in the management of CHD, a significant number of fatal and nonfatal CHD events still occur, which leads researchers to target other modifiable risk factors for CHD including low HDL-c (high density lipoprotein cholesterol). Although the torcetrapib experience was a major blow to CETP inhibition and indeed to the entire field of HDL-targeted therapeutics, it was...
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Cholesteryl ester transfer protein (CETP) has been identified as a novel target for increasing HDL cholesterol levels. In this report, we describe the biochemical characterization of anacetrapib, a potent inhibitor of CETP. To better understand the mechanism by which anacetrapib inhibits CETP activity, its biochemical properties were compared with CETP inhibitors from distinct structural classe...
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Among the noteworthy recent stories in the management and prevention of atherosclerotic cardiovascular disease (CVD) is the saga of the development of pharmacological inhibitors of cholesteryl ester transfer protein (CETP). Inhibiting CETP significantly raises plasma concentrations of high-density lipoprotein cholesterol, which has long been considered a marker of reduced CVD risk. However, the...
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ژورنال
عنوان ژورنال: Clinical Pharmacokinetics
سال: 2013
ISSN: 0312-5963,1179-1926
DOI: 10.1007/s40262-013-0071-8