Future Directions in Chronic Cough

Introduction: Refractory/unexplained chronic cough (RUCC) is a highly prevalent debilitating condition. The characteristics of RUCC suggest neuronal excitability. biological mechanisms leading to this in humans are uncertain but thought involve changes both the peripheral and central nervous system. Efficacy P2X purinoceptor 3 (P2X3) antagonists suggests role for extracellular adenosine triphosphate (ATP) RUCC. In guinea pigs, ATP release occurs response hypotonic saline, through transient receptor potential cation channel subfamily V member 4 (TRPV4)−ATP−P2X3 axis. Aims: review we discuss data from two European Respiratory Society 2022 abstracts RUCC, as well current insights future directions cough. Results: We show that saline challenge, measured by maximum evoked response, effectively discriminates healthy volunteers. low-dose morphine efficacious up 75% patients with side effects, experienced around 38% cases, can usually be managed. Further areas: treatable traits cough, existing pharmacological management options antitussives.