منابع مشابه
Regulated Membrane Fusion: Molecular Mechanisms and Machinery
Background Regulated exocytosis at the neuronal synapse is a multistep process starting with synaptic vesicle tethering at the active zone followed by vesicle priming and culminating in fast calcium-triggered membrane merger. Distinct protein-protein interactions forming macromolecular assemblies control individual steps and sequentially bring the two membranes into close proximity creating a h...
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Recombinant v- and t-SNARE proteins reconstituted into separate lipid bilayer vesicles assemble into SNAREpins-SNARE complexes linking two membranes. This leads to spontaneous fusion of the docked membranes at physiological temperature. Docked unfused intermediates can accumulate at lower temperatures and can fuse when brought to physiological temperature. A supply of unassembled v- and t-SNARE...
متن کاملMolecular machinery of mitochondrial fusion and fission.
Mitochondria generate energy by oxidative phosphorylation; play a crucial role in iron-sulfur cluster assembly; and participate in intermediary metabolism, calcium signaling, and apoptosis. They are bounded by a double membrane and contain 800 (yeast) to 1500 (human) different proteins. Although the vastmajorityofmitochondrial proteins are encoded in thenucleus and post-translationally imported...
متن کاملTriggering the measles virus membrane fusion machinery.
Paramyxoviruses contain glycoprotein fusion machineries that mediate membrane merger for infection. The molecular framework and mechanistic principles governing receptor-induced triggering of the machinery remain unknown. Using measles virus (MeV) fusion complexes, we demonstrate that receptor binding to only one dimer of the tetrameric attachment protein (H) dimer-of-dimers induces fusion-prot...
متن کاملNucleolar Assembly of the Rrna Processing Machinery in Living Cells
To understand how nuclear machineries are targeted to accurate locations during nuclear assembly, we investigated the pathway of the ribosomal RNA (rRNA) processing machinery towards ribosomal genes (nucleolar organizer regions [NORs]) at exit of mitosis. To follow in living cells two permanently transfected green fluorescence protein-tagged nucleolar proteins, fibrillarin and Nop52, from metap...
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ژورنال
عنوان ژورنال: Seibutsu Butsuri
سال: 1992
ISSN: 0582-4052,1347-4219
DOI: 10.2142/biophys.32.249