Fuse or die: Shaping mitochondrial fate during starvation

PKA isoforms coordinate mRNA fate during nutrient starvation

A variety of stress conditions induce mRNA and protein aggregation into mRNA silencing foci, but the signalling pathways mediating these responses are still elusive. Previously we demonstrated that PKA catalytic isoforms Tpk2 and Tpk3 localise with processing and stress bodies in Saccharomyces cerevisiae. Here, we show that Tpk2 and Tpk3 are associated with translation initiation factors Pab1 a...

Shaping the cell fate.

To fuse or not to fuse: what is your purpose?

Since the dawn of time, or at least the dawn of recombinant DNA technology (which for many of today's scientists is the same thing), investigators have been cloning and expressing heterologous proteins in a variety of different cells for a variety of different reasons. These range from cell biological studies looking at protein-protein interactions, post-translational modifications, and regulat...

To die or not to die.

This article presents the author's personal reflections and experiences in providing case management for patients with end-of-life issues. Through case examples and practical guidelines, the reader will gain an insight into dealing with terminal states in the acute care setting. References were drawn from recent literature on the subject, and were the stimulus to this piece.

The Cambrian "explosion": slow-fuse or megatonnage?

Clearly, the fossil record from the Cambrian period is an invaluable tool for deciphering animal evolution. Less clear, however, is how to integrate the paleontological information with molecular phylogeny and developmental biology data. Equally challenging is answering why the Cambrian period provided such a rich interval for the redeployment of genes that led to more complex body plans.