Further understanding human disease genes by comparing with housekeeping genes and other genes
نویسندگان
چکیده
منابع مشابه
Further defining housekeeping , or “ maintenance , ” genes
HOUSEKEEPING GENES are constitutively expressed to maintain cellular function. As such, they are presumed to produce the minimally essential transcripts necessary for normal cellular physiology. With the advent of microarray technology, it has recently become possible to identify at least the “starter set” of housekeeping genes, as exemplified by the work of Velculescu et al. (2), as well as by...
متن کاملHuman housekeeping genes are compact.
Genome Biol. 2, 1018 13 Gray, M.W. et al. (1999) Mitochondrial evolution. Science 283, 1476–1481 14 Lang, B.F. et al. (1999) A comparative genomics approach to the evolution of eukaryotes and their mitochondria. J. Eukaryot. Microbiol. 46, 320–326 15 Henze, K. and Martin, W. (2001) How do mitochondrial genes get into the nucleus? Trends Genet. 17, 383–387 16 Chinnery, P.F. (2003) Searching for ...
متن کاملDo Housekeeping Genes Exist?
The searching of human housekeeping (HK) genes has been a long quest since the emergence of transcriptomics, and is instrumental for us to understand the structure of genome and the fundamentals of biological processes. The resolved genes are frequently used in evolution studies and as normalization standards in quantitative gene-expression analysis. Within the past 20 years, more than a dozen ...
متن کاملOn the nature of human housekeeping genes.
Using a collection of expressed sequence tag (EST) data, we re-evaluated the correlation of tissue specificity with genomic structure, phyletic age, evolutionary rate and promoter architecture of human genes. We found that housekeeping genes are less compact and older than tissue-specific genes, and they evolve more slowly in terms of both coding and core promoter sequences. Housekeeping genes ...
متن کاملIdentification of Human Housekeeping Genes and Tissue-Selective Genes by Microarray Meta-Analysis
BACKGROUND Categorizing protein-encoding transcriptomes of normal tissues into housekeeping genes and tissue-selective genes is a fundamental step toward studies of genetic functions and genetic associations to tissue-specific diseases. Previous studies have been mainly based on a few data sets with limited samples in each tissue, which restrained the representativeness of their identified gene...
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ژورنال
عنوان ژورنال: BMC Genomics
سال: 2006
ISSN: 1471-2164
DOI: 10.1186/1471-2164-7-31