FURTHER SIMULATION STUDIES ON EVOLUTION BY GENE DUPLICATION
نویسندگان
چکیده
منابع مشابه
Simulating evolution by gene duplication.
By considering the recent finding that unequal crossing over and other molecular interactions are contributing to the evolution of multigene families, a model of the origin of repetitive genes was studied by Monte Carlo simulations. Starting from a single gene copy, how genetic systems evolve was examined under unequal crossing over, random drift and natural selection. Both beneficial and deter...
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The importance of gene duplication in supplying raw genetic material to biological evolution has been recognized since the 1930s. Recent genomic sequence data provide substantial evidence for the abundance of duplicated genes in all organisms surveyed. But how do newly duplicated genes survive and acquire novel functions, and what role does gene duplication play in the evolution of genomes and ...
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To test the theory that evolution by gene duplication occurs as a result of positive Darwinian selection that accompanies the acceleration of mutant substitutions, DNA sequences of recent duplication were analyzed by estimating the numbers of synonymous and nonsynonymous substitutions. For the troponin C family, at the period of differentiation of the fast and slow isoforms, amino acid substitu...
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Recent studies reveal that transmenbrane (TM) topology (the number of TM segments (TMSs), the TMS position and the orientation of TMS to the membrane lipid bilayer) evolves by internal gene duplication [1, 6]. A large number of TM proteins, such as Bacteriorhodopsin, Na/Ca exchanger and the major facilitator superfamily, have been recognized to have internal repeats that presumably has arisen f...
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Lynch and Conery (1) presented one of the first serious efforts to study the evolutionary fate of gene duplication using genomic sequence data. Their analysis led to several interesting observations, particularly with respect to the rate of gene duplication in eukaryotic genomes and the subsequent halflife of duplicates. These two parameters are of particular importance in studying the evolutio...
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ژورنال
عنوان ژورنال: Evolution
سال: 1988
ISSN: 0014-3820
DOI: 10.1111/j.1558-5646.1988.tb04140.x