Furrow Constriction in Animal Cell Cytokinesis

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Furrow constriction in animal cell cytokinesis.

Cytokinesis is the process of physical cleavage at the end of cell division; it proceeds by ingression of an acto-myosin furrow at the equator of the cell. Its failure leads to multinucleated cells and is a possible cause of tumorigenesis. Here, we calculate the full dynamics of furrow ingression and predict cytokinesis completion above a well-defined threshold of equatorial contractility. The ...

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Cytokinesis: Placing the Furrow in Context

A Caenorhabditis elegans mutant has been identified in which an ectopic myosin cap shifts the cleavage furrow relative to the spindle center. Surprisingly, the molecules that suppress this cap in wild-type embryos generate a cap in other asymmetrically dividing cells.

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Cleavage furrow formation and ingression during animal cytokinesis: a microtubule legacy.

Cytokinesis ensures the proper partitioning of the nuclear and cytoplasmic contents into independent daughter cells at the end of cell division. Although the metazoan mitotic spindle has been implicated in the placement and advancement of the cleavage furrow, the molecules responsible for these processes have remained elusive. Recent studies have provided insights into the role of different mic...

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Cytokinesis in animal cells.

Cytokinesis is both temporally and spatially coordinated with mitosis. It typically occurs only after the onset of anaphase chromosome separation as the cell leaves the mitotic phase of the cell cycle and enters interphase. Division usually occurs along a plane which bisects the interpolar axis of the mitotic spindle. This process lnsures that chromosomes segregated by the mitotic spindle becom...

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Mitochondria Localize to the Cleavage Furrow in Mammalian Cytokinesis

Mitochondria are dynamic organelles with multiple cellular functions, including ATP production, calcium buffering, and lipid biosynthesis. Several studies have shown that mitochondrial positioning is regulated by the cytoskeleton during cell division in several eukaryotic systems. However, the distribution of mitochondria during mammalian cytokinesis and whether the distribution is regulated by...

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ژورنال

عنوان ژورنال: Biophysical Journal

سال: 2014

ISSN: 0006-3495

DOI: 10.1016/j.bpj.2013.11.014