Furosemide/Non-Steroidal Anti-Inflammatory Drug–Drug Pharmaceutical Solids: Novel Opportunities in Drug Formulation

نویسندگان

چکیده

The design of drug–drug multicomponent pharmaceutical solids is one the latest drug development approaches in industry. Its purpose to modulate physicochemical properties active ingredients (APIs), most them already existing market, achieving improved bioavailability properties, especially on oral administration drugs. In this work, our efforts are focused mechanochemical synthesis and thorough solid-state characterization two cocrystals involving furosemide different non-steroidal anti-inflammatory drugs (NSAIDs) commonly prescribed together: ethenzamide piroxicam. Besides powder single crystal X-ray diffraction, infrared spectroscopy thermal analysis, stability, solubility tests were performed new solid materials. aim work was evaluating such APIs formulation, which revealed a improvement regarding NSAIDs but not furosemide. Further studies need be carried out evaluate interaction novel solids, looking for potential therapeutic alternatives.

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ژورنال

عنوان ژورنال: Crystals

سال: 2021

ISSN: ['2073-4352']

DOI: https://doi.org/10.3390/cryst11111339