Functional organization of the retrotransposon Ty from Saccharomyces cerevisiae: Ty protease is required for transposition.
نویسندگان
چکیده
منابع مشابه
Fitness effects of Ty transposition in Saccharomyces cerevisiae.
It has been suggested that the primary evolutionary role of transposable elements is negative and parasitic. Alternatively, the target specificity and gene regulatory capabilities of many transposable elements raise the possibility that transposable element-induced mutations are more likely to be adaptively favorable than other types of mutations. Populations of Saccharomyces cerevisiae contain...
متن کاملTy Elements of the Yeast Saccharomyces Cerevisiae
Transposable elements in the yeast Saccharomyces cerevisiae are a heterogeneous group of mobile genetic elements. Ty elements transpose via an intermediate RNA-molecule using the same replication and integration mechanisms as the metazoan retroviruses. Ty1 is a retrotransposons with life cycle very similar to that of oncogenes. This similarity provides an attractive model for virus-host interac...
متن کاملTempo and mode of Ty element evolution in Saccharomyces cerevisiae.
The Saccharomyces cerevisiae genome contains five families of long terminal repeat (LTR) retrotransposons, Ty1-Ty5. The sequencing of the S. cerevisiae genome provides an unprecedented opportunity to examine the patterns of molecular variation existing among the entire genomic complement of Ty retrotransposons. We report the results of an analysis of the nucleotide and amino acid sequence varia...
متن کاملTy element-induced temperature-sensitive mutations of Saccharomyces cerevisiae.
Temperature-sensitive mutants of Saccharomyces cerevisiae were isolated by insertional mutagenesis using the HIS3 marked retrotransposon TyH3HIS3. In such mutants, the TyHIS3 insertions are expected to identify loci which encode genes essential for cell growth at high temperatures but dispensable at low temperatures. Five mutations were isolated and named hit for high temperature growth. The hi...
متن کاملThe SPT3 gene is required for normal transcription of Ty elements in S. cerevisiae.
The transposable Ty elements consist of a central core, epsilon, flanked by direct repeats called deltas. In wild-type strains Ty transcripts initiate in one delta and terminate in the other. Insertion mutations caused by Ty elements have a wide variety of phenotypes, ranging from inhibition of gene expression to constitutive gene expression. Mutations in the SPT3 gene suppress these effects of...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular and Cellular Biology
سال: 1988
ISSN: 0270-7306,1098-5549
DOI: 10.1128/mcb.8.4.1421