Functional Impact of 10 Days of Bed Rest in Healthy Older Adults

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Effect of 10 days of bed rest on skeletal muscle in healthy older adults.

1. Lee JK, Grace KA, Taylor AJ. Effect of a pharmacy care program on medication adherence and persistence, blood pressure, and low density lipoprotein cholesterol: a randomized controlled trial. JAMA. 2006;296:2563-2571. 2. Naylor CD. Clinical decisions: from art to science and back again. Lancet. 2001; 358:523-524. 3. Whelton PK, Appel LJ, Espeland MA, et al; TONE Collaborative Research Group....

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Effect of β-hydroxy-β-methylbutyrate (HMB) on lean body mass during 10 days of bed rest in older adults.

BACKGROUND Loss of muscle mass due to prolonged bed rest decreases functional capacity and increases hospital morbidity and mortality in older adults. OBJECTIVE To determine if HMB, a leucine metabolite, is capable of attenuating muscle decline in healthy older adults during complete bed rest. DESIGN A randomized, controlled, double-blinded, parallel-group design study was carried out in 24...

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Re: Bed Rest Promotes Reductions in Walking Speed, Functional Parameters, and Aerobic Fitness in Older, Healthy Adults.

CONTEXT The exact relationship between the bed rest-induced loss of skeletal muscle and reductions in muscle strength and physical performance in the older individuals is still unclear. OBJECTIVE We examined the effect of 10 days of bed rest on changes in regional body composition, muscle strength, and functional status, and the relationship between these variables in older individuals. DES...

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The effect of 8 days of strict bed rest on the incretin effect in healthy volunteers.

Bed rest and physical inactivity are the consequences of hospital admission for many patients. Physical inactivity induces changes in glucose metabolism, but its effect on the incretin effect, which is reduced in, e.g., Type 2 diabetes, is unknown. To investigate how 8 days of strict bed rest affects the incretin effect, 10 healthy nonobese male volunteers underwent 8 days of strict bed rest. B...

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Markers of bone metabolism during 14 days of bed rest in young and older men

OBJECTIVE We aimed at comparing markers of bone metabolism during unloading in young and older men, and to assess countermeasure effectiveness. METHODS 16 older (60±2 years) and 8 younger men (23±3 years) underwent bed rest (BR) for 14 days. A subgroup of the Older performed cognitive training during BR and supplemented protein and potassium bicarbonate afterwards. Biochemical markers of bone...

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ژورنال

عنوان ژورنال: The Journals of Gerontology Series A: Biological Sciences and Medical Sciences

سال: 2008

ISSN: 1079-5006,1758-535X

DOI: 10.1093/gerona/63.10.1076