Functional genomics of AP-2α and AP-2γ in cancers: in silico study
نویسندگان
چکیده
منابع مشابه
epidemiological study of oral and pharyngeal cancers in kermanshah province from march 1993 to march 2006
چکیده ندارد.
15 صفحه اولRequirement for AP-2α in cardiac outflow tract morphogenesis
Most developing structures that express the transcription factor gene AP-2a are compromised in AP-2a mutant mouse embryos. Since the cardiac neural crest population is one prominent site of AP-2a expression, and because the neural crest is known to be required for normal cardiac morphogenesis, we have investigated the involvement of AP-2a in cardiac development. All AP-2a-deficient embryos exam...
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Transcription factor AP-2α involves in the process of mammalian embryonic development and tumorigenesis. Many studies have shown that AP-2α functions in association with other interacting proteins. In a two-hybrid screening, the regulatory subunit β of protein casein kinase 2 (CK2β) was identified as an interacting protein of AP-2α; we confirmed this interaction using in-vitro GST pull-down and...
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Transcription factor AP-2α is involved in many types of human cancers, but its role in hepatocellular carcinogenesis is largely unknown. In this study, we found that expression of AP-2α was low in 40% of human hepatocellular cancers compared with adjacent normal tissues by immunohistochemical analysis. Moreover, AP-2α expression was low or absent in hepatocellular cancer cell lines (HepG2, Hep3...
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Transcription factor AP-2 alpha (AP-2α or TFAP2A) is a newly identified prognostic marker of chemotherapy; its expression is positively correlated with chemosensitivity and survival of cancer patients. Using computational programs, we predicted that the coding region of AP-2α gene contains a potential miRNA response element (MRE) of miR-193a-5p, and the single nucleotide polymorphism (SNP) site...
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ژورنال
عنوان ژورنال: BMC Medical Genomics
سال: 2020
ISSN: 1755-8794
DOI: 10.1186/s12920-020-00823-9