Functional dissection of γ-aminobutyric acid metabolism in Neurospora crassa
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چکیده
منابع مشابه
Metabolism of nicotinamide and nicotinic acid in Neurospora crassa.
Nicotinic acid is outstanding among the B vitamins in that its metabolic fate has been very extensively investigated. These studies, however, have been carried out mostly in higher animals, and they have revealed that (i) N'-methylnicotinamide is, in general, the major end-product of the metabolism of both nicotinic acid and nicotinamide; (ii) nicotinuric acid, the glycine conjugate of nicotini...
متن کاملMetabolism of pyrimidine deoxyribonucleosides in Neurospora crassa.
The experiments in this report involve the following series of reactions which were previously demonstrated with purified enzyme preparations from Neurospora crassa: thymidine a yields thymine ribonucleoside b yields thymine c yields 5-hydroxymethyluracil d yields 5-formyluracil e yields uracil-5-carboxylic acid f yields uracil. The evidence for some of the reactions occurring in vivo has been ...
متن کاملGuanine uptake and metabolism in Neurospora crassa.
Guanine is transported into germinated conidia of Neurospora crassa by the general purine base transport system. Guanine uptake is inhibited by adenine and hypoxanthine but not xanthine. Guanine phosphoribosyltransferase (GPRTase) activity was demonstrated in cell extracts of wild-type germinated conidia. The Km for guanine ranged from 29 to 69 micro M in GPRTase assays; the Ki for hypoxanthine...
متن کاملMutants affecting thymidine metabolism in Neurospora crassa.
When (14)C-thymidine labeled only in the ring is administered to Neurospora crassa, the majority of the recovered label is found in the ribonucleic acid (RNA). Three mutants were isolated in which different steps are blocked in the pathway that converts the pyrimidine ring of thymidine to an RNA precursor. Evidence from genetic, nutritional, and accumulation studies with the three mutants shows...
متن کاملGlutamine metabolism and cycling in Neurospora crassa.
Evidence for the existence of a glutamine cycle in Neurospora crassa is reviewed. Through this cycle glutamine is converted into glutamate by glutamate synthase and catabolized by the glutamine transaminase-omega-amidase pathway, the products of which (2-oxoglutarate and ammonium) are the substrates for glutamate dehydrogenase-NADPH, which synthesizes glutamate. In the final step ammonium is as...
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ژورنال
عنوان ژورنال: General physiology and biophysics
سال: 2020
ISSN: 1338-4325
DOI: 10.4149/gpb_2020010