Functional coherence metrics in protein families
نویسندگان
چکیده
منابع مشابه
Functional coherence metrics in protein families
BACKGROUND Biological sequences, such as proteins, have been provided with annotations that assign functional information. These functional annotations are associations of proteins (or other biological sequences) with descriptors characterizing their biological roles. However, not all proteins are fully (or even at all) annotated. This annotation incompleteness limits our ability to make sound ...
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Protein functional annotation consists in associating proteins with textual descriptors elucidating their biological roles. The bulk of annotation is done via automated procedures that ultimately rely on annotation transfer. Despite a large number of existing protein annotation procedures the ever growing protein space is never completely annotated. One of the facets of annotation incompletenes...
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SUMMARY Burst After Duplication with Ancestral Sequence Predictions (BADASP) is a software package for identifying sites that may confer subfamily-specific biological functions in protein families following functional divergence of duplicated proteins. A given protein phylogeny is grouped into subfamilies based on orthology/paralogy relationships and/or user definitions. Ancestral sequences are...
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ژورنال
عنوان ژورنال: Journal of Biomedical Semantics
سال: 2016
ISSN: 2041-1480
DOI: 10.1186/s13326-016-0076-y