Function of monocytes and monocyte-derived macrophages in α1-antitrypsin deficiency
نویسندگان
چکیده
منابع مشابه
Function of monocytes and monocyte-derived macrophages in α1-antitrypsin deficiency.
α1-antitrypsin deficiency is the most widely recognised genetic disorder causing chronic obstructive pulmonary disease (COPD). Mutant Z α1-antitrypsin expression has previously been linked to intracellular accumulation and polymerisation of this proteinase inhibitor. Subsequently, this has been described to underlie an exaggerated endoplasmic reticulum stress response and enhanced nuclear facto...
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ژورنال
عنوان ژورنال: European Respiratory Journal
سال: 2014
ISSN: 0903-1936,1399-3003
DOI: 10.1183/09031936.00046114