Fully 3D‐Printed Cuff Electrode for Small Nerve Interfacing

Interfacing with the peripheral nervous system is a powerful method for diagnosing and treating several diseases, such as drug-resistant epilepsy depression. In most clinical applications, large nerves vagus hypoglossal nerve are targeted. Large carry multiple fibers, maintaining selectivity of specific target response demands complex stimulation strategies. As trunks bifurcate toward their distal ends, diameter number comprised fibers reduce. Consequently, interfacing small can provide increased fiber selectivity. However, size presents challenges to fabrication implantation suitable electrodes due fragility constrained environments. Here, cuff electrode that combines two-photon stereolithography 3D inkjet printing techniques selective in vivo introduced. The device easy implant, its be tailored dimensions. Its capability record selectively stimulate demonstrated by targeting locust's hind leg nerve.