Full-intensity and reduced-intensity allogeneic stem cell transplantation in AML
نویسندگان
چکیده
منابع مشابه
reduced intensity versus full myeloablative conditioning in allogeneic stem cell transplantation for acute myeloid leukemia
introduction: allogeneic hematopoietic stem cell transplantation (hsct) has been reported to be a successful curative treatment in aml patients. myeloablative conditioning (mac) is used more frequent as a preparing regimen. this study attempts to compare the outcome of patients who has received mac and reduced- intensity conditioning (ric). methods: totally, 618 patients with aml underwent hsct...
متن کاملReduced-intensity conditioning allogeneic stem cell transplantation in pediatric patients.
PURPOSE/OBJECTIVES To determine if children undergoing reduced-intensity conditioning allogeneic hematopoietic stem cell transplantation (RIC-AlloHSCT) have lower incidence of acute toxicities and, subsequently, require less supportive care than is required with myeloablative conditioning (MAC)-AlloHSCT. An additional purpose is to examine later outcomes by comparing 100-day transplantation-rel...
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Allogeneic stem cell transplantation (SCT) is an attractive form of immunotherapy for multiple myeloma (MM) due to well documented graft versus myeloma activity. High transplant related mortality with allogeneic SCT is currently the major limitation to wider use of this potentially curative modality. Mortality can be significantly reduced through the use of lower intensity conditioning regimens...
متن کاملAllogeneic hematopoietic stem cell transplantation (HSCT) after reduced intensity conditioning.
Allogeneic hematopoietic stem cell transplantation (HSCT) following myeloablative (conventional) conditioning regimen is associated with a high incidence of transplant-related morbidity and mortality, limiting its use to younger patients without medical co-morbidities. Over the past few years, it has become more evident that the alloreactivity of transplanted donor immunocompetent cells against...
متن کاملSTEM CELL TRANSPLANTATION Current update on reduced intensity regimens for allogeneic stem cell transplantation
Beside chemotherapy, immunotherapy represents an approach based on the more or less specific recognition of tumoral cells. Allogeneic stem cell transplantation (ASCT) has been used now for more than 3 decades in the treatment of malignant hemopathies. Several lines of evidence could show that donorderived immuno-competent effectors can exert a potent long lasting graft-versus-tumor activity. To...
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ژورنال
عنوان ژورنال: Bone Marrow Transplantation
سال: 2008
ISSN: 0268-3369,1476-5365
DOI: 10.1038/sj.bmt.1705975