منابع مشابه
Type III secretion system
The type III secretion system (T3SS) is a membrane-embedded nanomachine found in several Gram-negative bacteria. Upon contact between bacteria and host cells, the syringe-like T3SS (Figure 1) transfers proteins termed effectors from the bacterial cytosol to the cytoplasm or the plasma membrane of a single target cell. This is a major difference from secretion systems that merely release molecul...
متن کاملYersinia type III secretion
Pathogenic Yersinia spp (Yersinia pestis, Yersinia pseudotuberculosis, and Yersinia enterocolitica) have evolved an exquisite method for delivering powerful effectors into cells of the host immune system where they inhibit signaling cascades and block the cells' response to infection. Understanding the molecular mechanisms of this system has provided insight into the processes of phagocytosis a...
متن کاملUpdate on Bacterial Type III Secretion Type III Protein Secretion in Plant Pathogenic Bacteria
Many gram-negative plant and animal pathogenic bacteria employ a type III secretion system (T3SS) to subvert and colonize their respective host organisms. The T3SS injects effector proteins directly into the cytosol of eukaryotic cells and thus allows the manipulation of host cellular activities to the benefit of the pathogen. In plant pathogenic bacteria, T3SSs are encoded by hrp (for hypersen...
متن کاملSalmonella type III secretion-associated chaperones confer secretion-pathway specificity.
Type III protein secretion systems (TTSSs) are ancestrally related to the flagellar export system and are essential for the virulence of many bacteria pathogenic for humans, animals and plants. Most proteins destined to travel the TTSS pathway possess at least two domains that specifically target them to the secretion apparatus. One of the domains is located within the amino terminal first appr...
متن کاملTranslation/Secretion Coupling by Type III Secretion Systems
Type III secretion systems mediate export of virulence proteins and flagellar assembly subunits in Gram-negative bacteria. Chaperones specific to each class of secreted protein are believed to prevent degradation of the secreted substrates. We show that an additional role of chaperones may be to regulate translation of secreted proteins. We show that the chaperone FIgN is required for translati...
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ژورنال
عنوان ژورنال: Trends in Microbiology
سال: 2015
ISSN: 0966-842X
DOI: 10.1016/j.tim.2015.01.012