Fueling autoimmunity: type I interferon in autoimmune diseases
نویسندگان
چکیده
منابع مشابه
Type I interferon in systemic autoimmune diseases
Th e hypothesis that type I interferon plays a central role in the pathogenesis of systemic lupus erythematosus (SLE) has gained growing support in recent years [1-4]. Th e early data from the 1970s demonstrating increased functional interferon activity in lupus patient sera have been confi rmed and extended using current technologies that permit detection of the broad gene expression program i...
متن کاملType I interferon in organ-targeted autoimmune and inflammatory diseases
A significant role for IFNα in the pathogenesis of systemic lupus erythematosus is well supported, and clinical trials of anti-IFNα monoclonal antibodies are in progress in this disease. In other autoimmune diseases characterized by substantial inflammation and tissue destruction, the role of type I interferons is less clear. Gene expression analysis of peripheral blood cells from patients with...
متن کاملType I Interferon in Human Autoimmunity
The type I interferon system plays a critical role in host defense in health, and a growing body of literature suggests that type I interferon is a critical mediator of human autoimmune disease (1). Type I interferons function as a bridge between the innate and adaptive immune systems, and as such play an important role in setting thresholds for response against self antigens. Many investigator...
متن کاملThe importance of the type I interferon system in autoimmunity.
The type I interferon (IFN) system is our main defense against viral infections and consists of a large number of sensors of nucleic acid that can trigger the production of more than 15 different proteins with antiviral and immunostimulatory capacity. There are several observations suggesting an important role for this system in the etiopathogenesis of systemic lupus erythematosus (SLE) and oth...
متن کاملGenetic associations in type I interferon related pathways with autoimmunity
Type I interferons play an outstanding role in innate and adaptive immunity by enhancing functions of dendritic cells, inducing differentiation of monocytes, promoting immunoglobulin class switching in B cells and stimulating effector functions of T cells. The increased production of IFNα/β by plasmacytoid dendritic cells could be responsible for not only efficient antiviral defence, but it als...
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ژورنال
عنوان ژورنال: Expert Review of Clinical Immunology
سال: 2013
ISSN: 1744-666X,1744-8409
DOI: 10.1586/eci.12.106