Fructose and metabolic health: governed by hepatic glycogen status?
نویسندگان
چکیده
منابع مشابه
Stimulating effects of low-dose fructose on insulin-stimulated hepatic glycogen synthesis in humans.
Fructose has been shown to have a catalytic effect on glucokinase activity in vitro; however, its effects on hepatic glycogen metabolism in humans is unknown. To address this question, we used (13)C nuclear magnetic resonance (NMR) spectroscopy to noninvasively assess rates of hepatic glycogen synthesis and glycogenolysis under euglycemic (approximately 5 mmol/l) hyperinsulinemic conditions (ap...
متن کاملHigh liver glycogen in hereditary fructose intolerance.
A case of hereditary fructose intolerance is reported in a girl aged 2 years at the time of her death. She had apparently progressed normally until the age of 14 months. At 19 months she was admitted to hospital with failure to thrive, hepatomegaly, and superficial infections. Investigations revealed hypoglycaemia, persistent acidosis, aminoaciduria, and a high liver glycogen level which sugges...
متن کاملHepatic glycogen synthetase deficiency
In the 13 years since hepatic glycogen synthetase deficiency was first described in identical twins no further cases seem to have been observed. We report a child who had suffered from occasional morning convulsions since the age of 7. Three 24-hour metabolic profiles showed fasting hypoglycaemia, hyperketonaemia, but normal lactate. Hyperglycaemia and hyperlactataemia occurred after meals. Glu...
متن کاملHepatic Glycogen Synthetase Deficiency
Dykes, J. R. W., and Spencer-Peet, J. (1972). Archives of Disease in Childhood, 47, 558. Hepatic glycogen synthetase deficiency: further studies on a family. A family with hepatic glycogen synthetase deficiency originally studied in 1962, was restudied 7 years later. Blood glucose concentrations were measured after glucagon administration, and both blood glucose and plasma cortisol were measure...
متن کاملMuscle glycogen and metabolic regulation.
Muscle glycogen is an important fuel for contracting skeletal muscle during prolonged strenuous exercise, and glycogen depletion has been implicated in muscle fatigue. It is also apparent that glycogen availability can exert important effects on a range of metabolic and cellular processes. These processes include carbohydrate, fat and protein metabolism during exercise, post-exercise glycogen r...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 2019
ISSN: 0022-3751,1469-7793
DOI: 10.1113/jp277767