Fructooligosaccharide associated with celecoxib reduces the number of aberrant crypt foci in the colon of rats
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Fructooligosaccharide associated with celecoxib reduces the number of aberrant crypt foci in the colon of rats.
According to Burkitt's hypothesis, dietary fibres may protect against the development of colorectal cancer. In rats, studies have shown that only butyrate-producing fibres are protective. In parallel, in humans, non-steroidal anti-inflammatory drugs, which target cyclooxygenases, have been shown to display a protective effect against colorectal cancer. Among them, COX-2-selective inhibitors whi...
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The main objective of the present study was to test the hypothesis that exogenous insulin would enhance colon carcinogenesis. Thirty-six female Fischer 344 rats were fed ad libitum a low-fat rodent chow and given a single azoxymethane injection (20 mg/kg); one week later, they were randomized into two groups. Control rats were given a subcutaneous saline injection, 5 days/wk, and experimental r...
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ژورنال
عنوان ژورنال: Reproduction Nutrition Development
سال: 2003
ISSN: 0926-5287,1297-9708
DOI: 10.1051/rnd:2003028