From Studio to Rehab: A Debilitating Form of Anti-HMGCR Myopathy
نویسندگان
چکیده
Immune-mediated necrotizing myopathy is a subtype of immune-mediated associated with or without statin use. Statins, HMG-CoA reductase inhibitors, are the most prescribed medications for dyslipidemia. The statin-associated myopathic syndromes range from asymptomatic elevations in creatine kinase to severe debilitating muscle weakness rhabdomyolysis and elevated liver enzymes. Clinical improvement occurs upon discontinuation statins, but some patients do not recover completely. Diagnostic tests include electromyography, biopsy, myositis autoantibody panel, antibodies against HMGCR. Here, we present case anti-HMGCR-related atorvastatin.
منابع مشابه
Anti-HMGCR Myopathy
Anti-HMGCR myopathy was first recognized and characterized in patients with a history of statin exposure and immune-mediated necrotizing myopathy. After the discovery of anti-HMGCR autoantibodies, several international groups identified and characterized more patients, expanding the phenotypic spectrum of this disease to include pediatric patients and young adults without statin exposure and th...
متن کاملMyopathy with anti-HMGCR antibodies
Objective: To analyze clinical features and myopathology changes in muscle fibers, connective tissue, and vessels in 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) antibody– associated myopathies. Methods: Retrospective review of records and myopathologic features of 49 consecutive patients with myopathies and serum HMGCR antibodies. Results: Clinical features included onset age from 1...
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In addition to self-limited myotoxicity, statins have recently been shown to trigger an immune-mediated necrotizing myopathy (IMNM), which is distinguished from polymyositis (PM) and dermatomyositis (DM) by the absence of primary inflammation on muscle biopsy. Previously, we have shown that patients with statin-associated necrotizing myopathy express an autoantibody targeting 3-hydroxy-3methylg...
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OBJECTIVE To analyze clinical features and myopathology changes in muscle fibers, connective tissue, and vessels in 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) antibody-associated myopathies. METHODS Retrospective review of records and myopathologic features of 49 consecutive patients with myopathies and serum HMGCR antibodies. RESULTS Clinical features included onset age from 1...
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ژورنال
عنوان ژورنال: Cureus
سال: 2023
ISSN: ['2168-8184']
DOI: https://doi.org/10.7759/cureus.40825