From structure to cellular mechanism with infrared microspectroscopy

From structure to cellular mechanism with infrared microspectroscopy.

Current efforts in structural biology aim to integrate structural information within the context of cellular organization and function. X-rays and infrared radiation stand at opposite ends of the electromagnetic spectrum and act as complementary probes for achieving this goal. Intense and bright beams are produced by synchrotron radiation, and are efficiently used in the wavelength domain exten...

Cellular injury evidenced by impedance technology and infrared microspectroscopy.

Fourier Transform Infrared (FTIR) spectroscopy is finding increasing biological application, for example in the analysis of diseased tissues and cells, cell cycle studies and investigating the mechanisms of action of anticancer drugs. Cancer treatment studies routinely define the types of cell-drug responses as either total cell destruction by the drug (all cells die), moderate damage (cell det...

Infrared microspectroscopy in biological research.

Single Cancer Cell Detection by Near Infrared Microspectroscopy, Infrared Chemical Imaging and Fluorescence Microspectroscopy

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Mid-infrared Microspectroscopy of Difficult Samples Using Near-Field Photothermal Microspectroscopy

www.spectroscopyonl ine.com espite recent advances in Fourier transform-infrared (FT-IR) microspectroscopy and micro-attenuated total reflectance (ATR), for many types of samples there remains a need for even higher spatial resolution, or for a nondestructive method of recording localized mid-IR spectra from asreceived samples without the risk of damage or alteration by preparation techniques. ...