From kilovoltage to genetically predicted personalised radiotherapy: a quest to reduce breast radiotherapy side effects

A comparison of contralateral breast dose due to breast cancer radiotherapy using two different treatment machines in a radiotherapy center

Background: The radiation dose received by contralateral breast (CLB) is one of the concerns of breast radiotherapy, because it may lead to the induction of secondary breast cancer. The aim of this study was to evaluate the CLB surface dose in the breast treatment in Yazd radiotherapy center. Materials and Methods: The surface dose of CLB was measured using TLD dosimetry in 50 cancer breast pat...

Dose volume constraints to reduce rectal side-effects from prostate radiotherapy

Cardiovascular Side Effects of Radiotherapy in Breast Cancer

Nilsson, G. 2012. Cardiovascular Side Effects of Radiotherapy in Breast Cancer. Acta Universitatis Upsaliensis. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 800. 77 pp. Uppsala. ISBN 978-91-554-8446-0. The aim of the thesis was to study cardiovascular side effects of radiotherapy (RT) in breast cancer (BC). In a study base of 25,171 women with BC diagnos...

Idelalisib may have the potential to increase radiotherapy side effects

INTRODUCTION Idelalisib is approved for the treatment of relapsed chronic lymphocytic leukemia together with Rituximab and for monotherapy of follicular B-cell non-Hodgkin's lymphoma and small lymphocytic lymphoma. It is a potent and selective phosphatidylinositol 3-kinase-δ (PI3K-δ) inhibitor. PI3K-δ primarily is expressed in B-cells and prevents effectively proliferation in malignant B-cells....

Dose-volume constraints to reduce rectal side effects from prostate radiotherapy: evidence from MRC RT01 Trial ISRCTN 47772397.

PURPOSE Radical radiotherapy for prostate cancer is effective but dose limited because of the proximity of normal tissues. Comprehensive dose-volume analysis of the incidence of clinically relevant late rectal toxicities could indicate how the dose to the rectum should be constrained. Previous emphasis has been on constraining the mid-to-high dose range (>/=50 Gy). Evidence is emerging that low...