From Enhancers to Keratinocyte Cancers

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Enhancers, enhancers - from their discovery to today's universe of transcription enhancers.

Transcriptional enhancers are short (200-1500 base pairs) DNA segments that are able to dramatically boost transcription from the promoter of a target gene. Originally discovered in simian virus 40 (SV40), a small DNA virus, transcription enhancers were soon also found in immunoglobulin genes and other cellular genes as key determinants of cell-type-specific gene expression. Enhancers can exert...

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Recently, unique areas of transcriptional regulation termed super-enhancers have been identified and implicated in human disease. Defined by their magnitude of size, transcription factor density, and binding of transcriptional machinery, super-enhancers have been associated with genes driving cell differentiation. While their functions are not completely understood, it is clear that these regio...

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ژورنال

عنوان ژورنال: Journal of Investigative Dermatology

سال: 2021

ISSN: 0022-202X

DOI: 10.1016/j.jid.2020.11.008