From Drug Screening to Target Deconvolution: a Target-Based Drug Discovery Pipeline Using Leishmania Casein Kinase 1 Isoform 2 To Identify Compounds with Antileishmanial Activity
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چکیده
منابع مشابه
Target validation: A door to drug discovery.
From ancient times to today, drug discovery transitioned from serendipity to rationality over its long history. Proper drug target selection and validation are crucial to the discovery of new drugs. This review discusses the definition of drug targets and proposes several characteristics for drug targets. The limitations of the term 'target' itself are summarized. The drug target validation pro...
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Recent advances in our understanding of the cellular and molecular pathology of cancer are facilitating the development of new treatments which are expected to be both more active and less toxic than conventional therapies. These new treatments are known as ‘targeted therapies’ because they target lesions underlying the disease, as opposed to conventional cytotoxic drugs which act indiscriminat...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2016
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.00021-16