From chromatin to splicing: RNA-processing as a total artwork
نویسندگان
چکیده
منابع مشابه
From chromatin to splicing: RNA-processing as a total artwork.
RNA plays a central role in the determination of the phenotype of the cell. The molecular mechanisms involved in primary RNA synthesis and subsequent post-processing are not completely understood, but there is increasing evidence that they are more tightly coupled than previously expected. The analyses by a number of groups of recently published genome wide maps of chromatin structure have furt...
متن کاملRNA Processing: Wilms' tumour — the splicing connection?
Major isoforms of WT1--products of the tumour suppressor gene WT1, implicated in predisposition to Wilms' tumour--may preferentially interact with splicing factors, suggesting a role for WT1 in RNA processing.
متن کاملRNA splicing: advantages of parallel processing.
Parallel and sequential modes of RNA processing are systematically compared by an analysis of the relevant kinetic reaction schemes. The parallel mode is shown to be superior in the sense that it allows molecules to be processed with larger numbers of introns, smaller losses of immature intermediates, and shorter processing times. It also is more sensitive to variations in the rate constants fo...
متن کاملInterplay between chromatin and RNA processing.
The processing of pre-mRNAs, including the selection of polyadenylation sites, is influenced by the surrounding chromatin context. We review here recent studies in Arabidopsis thaliana highlighting the intricate and reciprocal interplay between chromatin state and RNA processing. The studies have revealed that transcription can be influenced by the presence, in gene introns, of combination of e...
متن کاملA transposable approach to RNA-seq from total RNA
The rapid progress of RNA-seq technology requires the development of simple, versatile tools that competently reflect RNA levels in the cell. We have developed the TotalScriptTM RNA-Seq Kit, a new, transposome-based directional library prep method suitable for a variety of RNA sample types and a range of input. TotalScript libraries exhibit high complexity, ~97–99% directionality and low rRNA c...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Epigenetics
سال: 2010
ISSN: 1559-2294,1559-2308
DOI: 10.4161/epi.5.3.11319