From Bupivacaine to Intralipid: Leading Edge

From Bupivacaine to Intralipid: Leading Edge

Intravenous lipid emulsion therapy was introduced as a treatment for local anesthetic toxicity it has shown couple of reversing and therapeutic efficacies for a number of different drug toxicities. In recent papers many different applications of Intralipid or oil containing products-Lipid Emulsion-have successfully experimented in critical care patients. In 1998 Dr. Weinberg began working on th...

Leading Edge Vortices

Leading-edge vortices that form at offdesign conditions can profoundly influence the aerodynamic characteristics of highly swept slender wings. predict wing geometry effects on the progressive spanwise development of leading-edge vortices is presented. This method, which can account for sweep, camber, twist, airfoil shape, flap deflections, and planform shape, is shown to be a useful tool for a...

Ascending aorta diameters measured by echocardiography using both leading edge-to-leading edge and inner edge-to-inner edge conventions in healthy volunteers.

AIMS Reference ranges of ascending aorta diameters (AAoD) for two-dimensional echocardiography (2DE) using inner edge (IE) convention are lacking, preventing the comparison of AAoD measurements by 2DE with those obtained by other imaging modalities. METHODS AND RESULTS We used harmonic imaging 2DE to prospectively study 218 healthy volunteers (56% women, 42 ± 15 years, 18-80 years). Measureme...

Life at the Leading Edge

Cell migration requires sustained forward movement of the plasma membrane at the cell's front or "leading edge." To date, researchers have uncovered four distinct ways of extending the membrane at the leading edge. In lamellipodia and filopodia, actin polymerization directly pushes the plasma membrane forward, whereas in invadopodia, actin polymerization couples with the extracellular delivery ...

DAS and small cells: A view from the leading edge