Frictional Response of Bovine Articular Cartilage Under Creep Loading Following Proteoglycan Digestion With Chondroitinase ABC
نویسندگان
چکیده
منابع مشابه
Effects of Chondroitinase ABC-Mediated Proteoglycan Digestion on Decellularization and Recellularization of Articular Cartilage
Articular cartilage has a limited capacity to heal itself and thus focal defects often result in the development of osteoarthritis. Current cartilage tissue engineering strategies seek to regenerate injured tissue by creating scaffolds that aim to mimic the unique structure and composition of native articular cartilage. Decellularization is a novel strategy that aims to preserve the bioactive f...
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Objective(s): Chondroitinase ABC (cABC) treatment improves functional recovery following spinal cord injury (SCI) through degrading inhibitory molecules to axon growth. However, cABC involvement in other pathological processes contributing to SCI remains to be investigated. Here, we studied the effect of cABC I on oxidative stress and inflammation developed in a rat model of SCI.Materials and M...
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Increasing tensile properties and collagen content is a recognized need in articular cartilage tissue engineering. This study tested the hypothesis that multiple applications of chondroitinase ABC (C-ABC), a glycosaminoglycan (GAG) degrading enzyme, could increase construct tensile properties in a scaffold-less approach for articular cartilage tissue engineering. Developing constructs were trea...
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Collagen content and tensile properties of engineered articular cartilage have remained inferior to glycosaminoglycan (GAG) content and compressive properties. Based on a cartilage explant study showing greater tensile properties after chondroitinase ABC (C-ABC) treatment, C-ABC as a strategy for cartilage tissue engineering was investigated. A scaffold-less approach was employed, wherein chond...
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INTRODUCTION: The viscoelastic behavior of articular cartilage is derived from complex interactions involving the fluid and the extracellular matrix (ECM) of proteoglycans (PG) and collagen fibrils. Enzymatic digestion of the ECM components makes it possible to study specific structure-function relationships of articular cartilage. To some extent, enzymatic treatment also simulates the patholog...
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ژورنال
عنوان ژورنال: Journal of Biomechanical Engineering
سال: 2005
ISSN: 0148-0731,1528-8951
DOI: 10.1115/1.2133764