Frequency of glutathione-S-transferase null-M1 and null-T1 genotypes among the Turabah population in Saudi Arabia
نویسندگان
چکیده
منابع مشابه
Frequency of glutathione-S-transferase null-M1 and null-T1 genotypes among the Turabah population in Saudi Arabia.
Glutathione-S-transferases (GST) are key phase II detoxifying enzymes that play critical roles in protection against products of oxidative stress and against electrophiles. Glutathione S-transferase mu (GST-M1) and theta (GST-T1) are isoforms of glutathione transferase enzymes that participate in the metabolism of a wide range of chemicals. Deletion variants that are associated with a lack of e...
متن کاملCombined glutathione S transferase M1/T1 null genotypes is associated with type 2 diabetes mellitus
BACKGROUND Due to new genetic insights, a considerably large number of genes and polymorphic gene variants are screened and linked with the complex pathogenesis of type 2 diabetes (DM). Our study aimed to investigate the association between the two isoforms of the glutathione S-transferase genes (Glutathione S transferase isoemzyme type M1- GSTM1 and Glutathione S transferase isoemzyme type T1-...
متن کامل"frequency of glutathione s-transferase m1 (gstm1) and gstt1 null genotypes in fars population (south of iran)"
the genes glutathione s-transferase m1 (gstm1) and gstt1 code for cytosolic enzymes gstµ and gstθ, respectively, which are involved in phase ii metabolism. in human, both genes may be deleted. in the present study, the genetic polymorphisms of gstm1 and gstt1 were detected by pcr method in 236 healthy individuals from shiraz population, fars province, south of iran. the frequency of gstm1 and g...
متن کاملFrequency of Null Phenotypes of Glutathione S-Transferase M1 and T1 among the Populations of Tabuk (Northwestern Part of Saudi Arabia)
Background: The variability in the distribution of the null phenotypes of GSTM1 and GSTT1, due to total or partial gene deletion resulting in the lack of the active enzyme, has been reported in different populations, especially in ethnically well-defined groups but not in Tabuk. This study investigated the variability in the distribution of the null phenotypes of GSTM1 and GSTT1 in the populati...
متن کاملprevalence of null genotypes of glutathione s-transferase t1 (gstt1) and m1 (gstm1) in seven iranian populations
background: previous studies have revealed significant differences between populations for genotypic frequencies of glutathione s-transferase t1 ( gstt1 ) and m1 ( gstm1 ) polymorphisms. in order to find the frequency of the null genotypes of gstm1 and gstt1 in iranian populations, the present study was carried out. methods: the total study subjects consisted of 1340 unrelated healthy muslims/i...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Genetics and Molecular Research
سال: 2015
ISSN: 1676-5680
DOI: 10.4238/2015.december.14.13