Free light chains in the cerebrospinal fluid.
نویسندگان
چکیده
منابع مشابه
Free light chains in the cerebrospinal fluid: an indicator of recent immunological stimulation.
A group of 38 patients with immunoglobulin free light chains (kappa and/or lambda) in the cerebrospinal fluid was studied. Only five of them showed one band of kappa free light chains, 36 of them showed one or more bands of lambda free light chains. There were 33 multiple sclerosis patients among them and they were compared with 33 control multiple sclerosis patients who did not have free light...
متن کاملKappa free light chains in cerebrospinal fluid as markers of intrathecal immunoglobulin synthesis.
BACKGROUND Intrathecal immunoglobulin synthesis is observed in several inflammatory disorders of the central nervous system, but its detection by current laboratory tests is either tedious or relatively insensitive. We assessed the diagnostic accuracy of an assay for kappa free light chains (kappaFLC) in cerebrospinal fluid (CSF) and serum, and compared it with traditional tests for intrathecal...
متن کاملKappa Free Light Chains in Cerebrospinal Fluid of Patients with Identified Oligoclonal Immunoglobulin G.
BACKGROUND Production of kappa free light chains (KFLC) represents a part of humoral immune response, along with the synthesis of intrathecal immunoglobulins. Increased concentrations of immunoglobulin G light chains, kappa and lambda chains, were identified through research of numerous diseases of central nervous system. The qualitative method of isoelectric focusing (IEF) followed by immunofi...
متن کاملHigh sensitivity and specificity of elevated cerebrospinal fluid kappa free light chains in suspected multiple sclerosis.
Cerebrospinal fluid (CSF) analysis is routinely used in the diagnostic work-up of multiple sclerosis (MS), by detecting CSF-specific oligoclonal bands (OCB). More recently, several studies have reported CSF free light chains (FLC) as an alternative. We show that absolute CSF κFLC concentrations were highly sensitive - more than OCB testing - and specific for clinically isolated syndrome, relaps...
متن کاملCerebrospinal fluid free kappa light chains versus IgG findings in neurological disorders: qualitative and quantitative measurements.
In this study free kappa light chains in cerebrospinal fluid (CSF) were determined both by an affinity mediated capillary blotting technique after isoelectric focusing (IEF) in agarose gel and by a quantitative enzyme linked immunosorbent assay (ELISA). The free kappa results were compared with the IgG findings in 4 neurological patient groups with a distinct CSF IgG pattern: (1) CSF without ol...
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ژورنال
عنوان ژورنال: Journal of Neurology, Neurosurgery & Psychiatry
سال: 1986
ISSN: 0022-3050
DOI: 10.1136/jnnp.49.7.845-b