منابع مشابه
Free erythrocyte protoporphyrin.
Porphyrins are widely distributed in living cells throughout nature and play essential roles in various metabolic processes such as photosynthesis, transportation of oxygen and cellular respiration. In man the most important of the porphyrins is protoporphyrin 9, type III, which in combination with iron and specific proteins forms such compounds as hemoglobin, myoglobin, cytochrome, peroxidase ...
متن کاملEFFECT OF CHRONIC LEAD POISONING ON ERYTHROCYTE PROTOPORPHYRIN IN RATS
Research has shown that exposure to lead may have adverse effects at different blood lead concentrations. Lead inhibits at least two enzymes that are essential for the formation of heme, and because of the interaction of lead with these enzymes, no iron is inserted into protoporphyrin. Therefore the concentration of protoporphyrin increases in erythrocytes. The concentration of lead was mea...
متن کاملFree erythrocyte protoporphyrin and zinc protoporphyrin measurements compared as primary screening methods for detection of lead poisoning.
We compared two commonly used primary screening methods (FEP and ZnP) for detecting Pb poisoning in children, used according to three major protocols. The results showed that FEP and ZnP values were comparable for only 36% of the children examined; 54% had FEP greater than ZnP and 10% had ZnP greater than FEP. One would identify approximately twice as many children with Pb greater than 300 micr...
متن کاملSPECTROPHOTOMETRIC MICROMETHOD FOR THE QUANTITATIVE DETERMINATION OF THE FREE ERYTHROCYTE PROTOPORPHYRIN” BY MOISl% GRINSTEINt
Interesthas developed recently (l-3) in the significance of the free protoporphyrin which van den Bergh and Hyman (4) reported in 1928 as being present in human erythrocytes. This “erythrocyte protoporphyrin” (EP) is identical with the protoporphyrin which, in combination with iron and globin, forms hemoglobin (1, 5). An increase in the quantity of free EP has been observed in immature erythroc...
متن کاملThe response of free erythrocyte protoporphyrin to pyridoxine therapy in a patient with sideroachrestic (sideroblastic) anemia.
By G. R. LEE, G. E. CARTWRIGHT AND M. M. \VINTROBE F’ EILMEYER has applied the term “sideroachrestic anemia” to conditions characterized by the association of hypochromic anemia with excessive iron storage.’ In referring to the same syndrome, Mollin and others2 prefer the designation “sideroblastic anemia,” a term which emphasizes the importance of abnormal iron accumulation in erythrohlasts. C...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1950
ISSN: 0021-9738
DOI: 10.1172/jci102324