Foxo1 regulates marginal zone B-cell development
نویسندگان
چکیده
منابع مشابه
Marginal Zone B-cell lymphoma
Extra-nodal MZBCL of MALT type (7% of all NHL) is an indolent disease involving most often the stomach, where it usually follows chronic gastritis due to Helicobacter pylori (HP) infection. The disease may also localize in the lung, the thyroid, the salivary gland, the orbit. Splenic MZBCL (1% of all NHL on histologic samples) usually, though not invariably, presents splenomegaly associated cir...
متن کاملNodal marginal zone B-cell lymphomas may arise from different subsets of marginal zone B lymphocytes.
Nodal marginal zone B-cell lymphoma (MZL) is a rare and not extensively studied entity that accounts for approximately 2% of all non-Hodgkin lymphomas. Complementarity-determining regions 2 and 3 (CDR2, CDR3) of the immunoglobulin heavy-chain variable region (V(H)) genes were amplified by polymerase chain reaction (PCR), cloned, and sequenced in 8 patients with nodal MZL. All showed a potential...
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Primary cutaneous marginal zone B-cell lymphoma (PCMZL) is included as one of the major types of primary cutaneous B-cell lymphoma in the revised World Health Organization-European Organization for Research and Treatment of Cancer classification. Clinically, PCMZL is an indolent disease and has an excellent prognosis. PCMZL is composed of a polymorphous infiltrate that includes centrocyte-like,...
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Selection of recently formed B cells into the follicular or marginal zone (MZ) compartments is proposed to occur by way of proliferative intermediates expressing high levels of CD21/35 and CD23. However, we show that CD21/35(high) CD23(+) splenocytes are not enriched for proliferative cells, and do not contribute substantially to the generation of follicular B cells. Instead, ontogenic relation...
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in our understanding of hemogenic endothelium induction, many questions remain. ncor2 is expressed throughout the aorta and controls expression of arterial markers throughout the vessel, yet loss of ncor2 only affects hemogenic endothelial formation. What other factors restrict the function of ncor2 within the presumptive hemogenic endothelial cells? Does ncor2 regulate expression of c-fos, veg...
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ژورنال
عنوان ژورنال: European Journal of Immunology
سال: 2010
ISSN: 0014-2980
DOI: 10.1002/eji.200939817