FOXA1 potentiates lineage-specific enhancer activation through modulating TET1 expression and function
نویسندگان
چکیده
منابع مشابه
FOXA1 potentiates lineage-specific enhancer activation through modulating TET1 expression and function
Forkhead box A1 (FOXA1) is an FKHD family protein that plays pioneering roles in lineage-specific enhancer activation and gene transcription. Through genome-wide location analyses, here we show that FOXA1 expression and occupancy are, in turn, required for the maintenance of these epigenetic signatures, namely DNA hypomethylation and histone 3 lysine 4 methylation. Mechanistically, this involve...
متن کاملFoxA1 Translates Epigenetic Signatures into Enhancer-Driven Lineage-Specific Transcription
Complex organisms require tissue-specific transcriptional programs, yet little is known about how these are established. The transcription factor FoxA1 is thought to contribute to gene regulation through its ability to act as a pioneer factor binding to nucleosomal DNA. Through genome-wide positional analyses, we demonstrate that FoxA1 cell type-specific functions rely primarily on differential...
متن کاملA Novel Approach to Assay DNA Methylation in Prostate Cancer
Forkhead box A1 (FOXA1) is an FKHD family pro-tein that plays pioneering roles in lineage-specificenhancer activation and gene transcription. Throughgenome-wide location analyses, here we show thatFOXA1 expression and occupancy are, in turn, re-quired for the maintenance of these epigeneticsignatures, namely DNA hypomethylation and his-tone 3 lysine 4 methylation. Me...
متن کاملBrg1 modulates enhancer activation in mesoderm lineage commitment
The interplay between different levels of gene regulation in modulating developmental transcriptional programs, such as histone modifications and chromatin remodeling, is not well understood. Here, we show that the chromatin remodeling factor Brg1 is required for enhancer activation in mesoderm induction. In an embryonic stem cell-based directed differentiation assay, the absence of Brg1 result...
متن کاملA lineage specific enhancer drives Otx2 expression in teleost organizer tissues
In mouse Otx2 plays essential roles in anterior-posterior axis formation and head development in anterior visceral endoderm and anterior mesendoderm. The Otx2 expression in these sites is regulated by VE and CM enhancers at the 5' proximal to the translation start site, and we proposed that these enhancers would have been established in ancestral sarcoptergians after divergence from actinopteri...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2016
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/gkw498