Formulation optimization and evaluation of Cefdinir nanosuspension using 23 Factorial design

Investigation of formulation variables affecting the properties of lamotrigine nanosuspension using fractional factorial design

BACKGROUND AND THE PURPOSE OF THE STUDY Lamotrigine (LMG) undergoes extensive hepatic metabolism upon oral administration and its absorption is affected in the presence of food. This study was aimed to develop nanosuspension of LMG and investigate its formulation characteristics using L(9) orthogonal array. METHODS Nanosuspension was prepared using emulsification-solvent diffusion method. All...

Formulation and Evaluation of Floating Nateglinide Tablets Using Factorial Design

Nateglinide is a novel, highly physiologic, glucose regulator recently approved for the treatment of type-2 diabetes mellitus. Nateglinide has a rapid onset and short duration of insulinotropic action that results in reduction of glucose level. The purpose of this study to develop a floating tablet of Nateglinide to enhance its bioavailability and sustained action. In the present study a 32 ful...

Application of Factorial Design for Optimization of Spectrophotometric Determination of Cefdinir Using MBTH

The target of the present study is to use experimental design in screening and optimizing experimental variables to develop a spectrophotometric method for determination of Cefdinir (CFN) antibiotic. The proposed method is based on the oxidative coupling reaction of CFN with 3methylbenzothiazolinone-2hydrazone (MBTH) in presence of FeCl3 in acidic medium forming a green colored chromogen measur...

Formulation Optimization and In-vitro Evaluation of Oral Floating Captopril Matrix Tablets using Factorial Design

Purpose: To develop a zero-order sustained release floating formulation of captopril, and optimize its drug release for enhanced oral bioavailability. Methods: A relatively new approach, 3 full factorial design, was used to formulate floating captopril matrix tablets and to systematically optimize its drug release using varying levels of xanthan gum and hydroxypropyl methylcellulose (HPMC) K100...

formulation and optimization of pseudoephedrine and loratadine pellets using factorial design