FORMULATION OF FLUCONAZOLE AS TOPICAL ANTIFUNGAL GELS BY MICROSPONGE BASED DELIVERY SYSTEMS
نویسندگان
چکیده
منابع مشابه
Formulation and In-Vitro Evaluation of Fluconazole Loaded Microsponge Gel For Topical Sustained Delivery
The objective of present work was to formulate and evaluate Fluconazole (FLZ) microsponges using quasi emulsion solvent diffusion technique and microsponge gel by using carbopol. Microsponges containing FLZ were obtained successfully with different proportions of ethyl cellulose polymer (EC). The formulations were studied for particle size and physical characterization. The physical characteriz...
متن کاملFormulation and in vitro evaluation of fluconazole topical gels
Aim: Topical drug delivery of fluconazole, an antifungal drug, in gel form was formulated to avoid the side effect of the oral route. Methodology: Different polymers; Sodium carboxymethyl cellulose, Sodium alginate, Carbopol 934P, Hydroxypropylmethyl cellulose, Pluronic F-127 and hydroxypropyl cellulose, were used. The compatibility of fluconazole and different gelling polymer was assessed thro...
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Invasive fungal infections can be devastating, especially in immunocompromized patients. Oral administration of fluconazole (FLZ) often produces gastric irritation, heart-burn, vomiting and sometimes patient can develop ulceration resulting in a less patient compliance with long term therapy. The aim of the present study was to formulate topical microsponge-based delivery system containing FLZ ...
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Background. Oxybenzone, a broad spectrum sunscreen agent widely used in the form of lotion and cream, has been reported to cause skin irritation, dermatitis, and systemic absorption. Aim. The objective of the present study was to formulate oxybenzone loaded microsponge gel for enhanced sun protection factor with reduced toxicity. Material and Method. Microsponge for topical delivery of oxybenzo...
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In the present study controlled release formulation of Indomethacin microsponges were prepared by using Eudragit RS 100, pH independent release retardant polymer and PVA, stabilizer or emulsifier. Microsponges were prepared by Quasi emulsion solvent diffusion method by changing drug polymer ratio (3:1, 4:1, 5:1) and process was optimized. Microsponges were evaluated by micromeritic properties, ...
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ژورنال
عنوان ژورنال: INDONESIAN JOURNAL OF PHARMACY
سال: 2017
ISSN: 2338-9486,2338-9427
DOI: 10.14499/indonesianjpharm28iss3pp158