Formulation and Optimization of Sodium Alginate Polymer Film as a Buccal Mucoadhesive Drug Delivery System Containing Cetirizine Dihydrochloride
نویسندگان
چکیده
Currently, pharmaceutical companies are working on innovative methods, processes and products. Oral mucoadhesive systems, such as tablets, gels, polymer films, among these possible systems possess many advantages, including the possibility to be applied in swallowing problems. The present study focused formulating buccal films investigating physical physical–chemical properties of films. Sodium alginate (SA) hydroxypropyl methylcellulose (HPMC) were used film-forming agents, glycerol (GLY) was added a plasticizer, cetirizine dihydrochloride (CTZ) an active ingredient (API). prepared at room temperature with solvent casting method by mixed two-level three-level factorial designs. thickness, tensile strength (hardness), mucoadhesivity, surface free energy (SFE), FTIR, Raman spectra, well dissolution investigated. investigations showed that GLY can reduce mucoadhesivity CTZ increase distribution proved homogeneous API could dissolve completely from all We conclude 1% 3% concentrations appropriate formulated for application mucosa drug delivery system.
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ژورنال
عنوان ژورنال: Pharmaceutics
سال: 2021
ISSN: ['1999-4923']
DOI: https://doi.org/10.3390/pharmaceutics13050619